MicroRNAs in Solid Tumors

Discovery of microRNAs and other small RNAs in solid tumors

MicroRNAs (miRNAs) are ∼22-nt long, non-coding RNAs that regulate gene silencing. It is known that many human miRNAs are deregulated in numerous types of tumors. Here we report the sequencing of small RNAs (17-25 nt) from 23 breast, bladder, colon and lung tumor samples using high throughput sequencing. We identified 49 novel miRNA and miR-sized small RNAs. We further validated the expression o...

Serum microRNAs in childhood tumors 1 Solid tumors of childhood display specific serum microRNA profiles

1 Solid tumors of childhood display specific serum microRNA profiles Matthew J. Murray, Katie L. Raby, Harpreet K. Saini, Shivani Bailey, Sophie V. Wool, Jane M. Tunnacliffe, Anton J. Enright, James C. Nicholson, Nicholas Coleman. 1 Department of Paediatric Haematology and Oncology, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0QQ, UK 2 Department of Pathology, University of Cambridge, Te...

Meningeal carcinomatosis in solid tumors.

The involvement of the leptomeninges by metastatic tumors can be observed in solid tumors, in which case it is termed meningeal carcinomatosis (MC), and in lymphoproliferative malignant disease. It is more common in breast and lung cancer, as well as melanoma, with adenocarcinoma being the most frequent histological type. MC is usually a late event, with disseminated and progressive disease alr...

Oncogene Addiction in Solid Tumors

Genealogies in Growing Solid Tumors

Over the past two decades, the theory of tumor evolution has largely focused on the selective sweeps model. According to this theory, tumors evolve by a succession of clonal expansions that are initiated by driver mutations that have a fitness advantage over the resident types. A 2015 study of colon cancer [44] has suggested an alternative theory of tumor evolution, the so-called Big Bang model...